A major advancement in recent years was the identification of germline and somatic alterations in a significant number of PCa patients, e.g. mutations in genes associated with the homologous recombination repair (HRR) pathway, e.g. BRCA1, BRCA2 and ATM, in approximately 25% of patients with mCRPC [18]. Here, BRCA2 is linked to posterior cortical atrophy.