For instance, other costimulatory signals could be usedto boost and control T-cell function and fate, e.g., agonistic CD2,4-1BB, or OX-40 antibodies.−,  When antigen-specific T-cellexpansion is necessary, a diverse repertoire of pMHC complexes wouldprovide the opportunity to generate T-cell responses specific to abroad repertoire of tumor-associated antigens or neoantigens. The gene discussed is TNFRSF4; the disease is neoplasm.