During sepsis, HDL metabolism is altered22 and HDL metabolism might be targeted for the treatment of endotoxemia, either by directly supplementing HDL or APO‐A13, 7, 23, 24, 25 or by acting on PLTP with the aim of enhancing LPS transfer to lipoprotein.10, 12. Here, PLTP is linked to serum lipopolysaccharide activity.