The PI3K/Akt signaling pathway can be inhibited by up-regulation of lncRNA MEG3, which mitigated the cognitive deficits and pathological damage to hippocampal neurons apoptosis in rats with Alzheimer’s disease (AD) [9].Transcriptome profiling revealed that lncRNA HCG27 differentially expressed in ischemic stroke [10]. This evidence concerns the gene AKT1 and Alzheimer disease.