Experimental evidence suggests that vitamin D3 directly inhibits IL-17 gene transcription, thereby obstructing the maturation of IL-17-secreting T cells and attenuating a mixed inflammatory infiltrate of lymphocytes and neutrophils (Abdel-Wahab et al. 2022).It is also important to note that polymorphisms in the VDR gene may increase the risk of acne vulgaris. This evidence concerns the gene VDR and acne.