Here, we found that 10 μM GW4869 had a significant inhibitory effect on generation of PC-3 and RM-1 exosomes, up to 57% or 54% respectively (Fig. 6A), and after culturing with CM-GW4869, the proliferation rate of CD8+ T cells increased (Fig. 6B) and the number of apoptotic cells decreased compared with CD8+ T cells induced by PCa exosomes (Fig. 6C). The gene discussed is CD8A; the disease is posterior cortical atrophy.