They regulate gene expression by altering gene accessibility or transcriptional activity.LINC02560 recruits specific epigenetic modification enzymes to the promoter region of the GLI2 gene, It regulates the transcriptional activity of GLI2 by affecting its methylation status or histone modification pattern.This regulatory mechanism leads to the abnormal increase of GLI2 expression in hepatocellular carcinoma, which aggravates the malignant biological behavior of hepatocytes. The gene discussed is GLI2; the disease is hepatocellular carcinoma.