After obtaining the SUVR for the Desikan-Killiany atlas regions with both processing methods, global tau SUVR were calculated from specific AD regions of interest (ROIs): (a) medial temporal lobe (MTL), (b) early to late AD related areas (global AD meta-ROI) according to [22], (c) early AD meta-ROI as the most discriminative for tau status for cognitively normal population according to [23], (d) lateral temporal ROI, (e) and Braak regions. The gene discussed is MAPT; the disease is Alzheimer disease.