Bicluster-specific clusters reflected the increased abundance of functional integrity features (that is, podocyte physiology and metabolism) in control specimens, and of pathogenic features in DKD samples (that is, macrophage infiltration, immune activation, AIFM1–TRPC6 signalling, endoplasmic reticulum (ER) stress, ECM remodelling, and GR, β-catenin, histone H2B and ubiquitylation dysfunction). Here, TRPC6 is linked to diabetic kidney disease.