TNF and Sepsis: The correlation analysis revealed that higher peak levels of biomarkers such as IL-6, TNF, IL-18, IL-10, IL-1Ra, GDF15, MDA, u-CHI3L1, and s-CHI3L1 during the first seven days of ICU admission were associated with poorer outcomes, including increased mortality, higher SOFA scores, and a higher incidence of sepsis/septic shock and AKI.