In contrast, carriers of gBRCA1/2 PVs/LPVs represented only 11.6% of the BC cohort, which points to the stronger influential role of family history as BC predisposing64,65 and highlights the need to explore other genetic factors in patients who test negative for BRCA1/2 PVs/LPVs. The gene discussed is BRCA1; the disease is breast cancer.