Recent study discovered that FASN/PA-mediated Wnt3A (Cys77) palmitoylation promotes Wnt3A membrane localization and the translocation of β-catenin into the nucleus, further activating Wnt3A/β-catenin pathway and promoting the formation of EMT phenotype in esophageal squamous cell carcinoma [138]. This evidence concerns the gene WNT3A and esophageal squamous cell carcinoma.