ACLY and colorectal carcinoma: Similarly, Shan et al. demonstrated that ZDHHC6 directly palmitoylates and stabilizes peroxisome proliferator-activated receptor-gamma (PPARγ) at the Cys313 site within its DNA-binding domain, enhancing its nuclear translocation and activating the ATP citrate lyase (ACLY) transcription-related metabolic pathway, and thereby promoting fatty acid biosynthesis and CRC progression.