Further study suggested that ATG16L1 knockout enhanced stimulator of interferon genes (STING) palmitoylation, thus promoted STING trafficking from the endoplasmic reticulum to the Golgi, and activated downstream STING signaling, promoting proinflammatory and profibrotic cytokines secretion, resulting in hepatic steatosis and hepatic stellate cells activation [89]. The gene discussed is STING1; the disease is Hepatic steatosis.