PHGDH and hepatocellular carcinoma: It is now well established that various RNA species, including lncRNAs, miRNAs, circRNAs and mRNAs, can interact with RBPs, with mRNAs representing one of the most prominent targets.16 Therefore, to identify novel RBPs interacting with mRNA, we applied a UV crosslinking-based RNA interactome capture approach to HCC cells for the first time.17,18 We identified phosphoglycerate dehydrogenase (PHGDH) as a potential RBP among the candidate proteins enriched in metabolic pathways.