However, at 52 weeks of age, Jnk1Δhepa/2-/- but not Jnk2-/- mice developed cyst formation and increased ductular reaction associated with a mild increase in typical serum parameters of liver damage, including AST, alanine aminotransferase (ALT), and alkaline phosphatase (AP).17 The gene discussed is DHCR7-DT; the disease is cyst.