Jnk2-regulated genes in hepatocytes are involved in energy and BA metabolism (Sult2a2, Cyp2e1, Cyp2c19, Ugt1a1 and Abcb1b), whereas in nonhepatocytes Jnk2 controls inflammatory processes (Saa1/2, Ifi202b, Ly6DTrim12, and Nfkb) (Figure 7D), suggesting that Jnk2 in nonhepatocytes modulates the proinflammatory response during cholestasis. This evidence concerns the gene CYP2C19 and cholestasis.