In summary, expression of stabilized CTNNB1 resulted in a lissencephaly type 1–like phenotype with reduction of Reelin levels, whereas a coactivation of both LIN28A overexpression and stabilized CTNNB1 rescued the Reelin levels but led to a porous pial border and mislocalized CRs resulting in a lissencephaly type 2–like phenotype. Here, CTNNB1 is linked to cobblestone lissencephaly.