Increased expression of a set of homeodomain (HD) proteins, including HoxA9 and HoxA10, is characteristic of AML with translocations or internal duplication of the KMT2A gene (also known as the Mixed Lineage Leukemia 1 gene; MLL1), translocation of the MYST3-CREBBP genes, or a normal cytogenetics subset with adverse outcomes (1, 2, 3, 4). This evidence concerns the gene CREBBP and acute myeloid leukemia.