To determine the contribution of Gcn1-degradation to leukemia suppression by Triad1, we co-transduced murine bone marrow cells with an MLL1-ELL expression vector plus vectors to express Triad1-specific shRNAs, Gcn1-specific shRNAs, Triad1-plus Gcn1-specific shRNAs, or scrambled controls. This evidence concerns the gene GCN1 and leukemia.