Gcn1-stabilization increased translation of anti-apoptotic proteins Bcl6 and Nfkb2, signal modulators Stat5a and Shp1, and the emergency granulopoiesis mediator IL1R but decreased translation of Caspases, Fanconi DNA repair proteins, and leukemia suppressors Ezh2 and Idh1 ((13, 41, 42, 43)). Here, IDH1 is linked to leukemia.