RNA-sequencing (RNA-seq) of MYB-expressing pancreatic cancer cells under normoxia (21 % O2) and hypoxia (1.0 % O2) identified 2156 differentially expressed genes (DEGs) (fold change ≥1.5, p value < 0.05), of which 1339 were upregulated and 817 downregulated in hypoxia-exposed cells (Fig. 4A). Here, MYB is linked to familial pancreatic carcinoma.