Furthermore, five genes (KRT19, ALDOA, CLDN4, RAB27B, and GJB5) among the top 10 % coregulated genes were identified to have significantly elevated expression in pancreatic cancer compared to the normal pancreas (Fig. 6A–E, Supplementary Fig. S7A–S7E). This evidence concerns the gene GJB5 and familial pancreatic carcinoma.