Even after multivariable adjustment, patients receiving beta-blockers or SGLT2 inhibitors in phenogroup 5 had a significantly higher risk of HF hospitalization (HR: 2.71; 95% CI: 1.06-6.97 and HR: 5.40; 95% CI: 2.36-12.32, respectively) (Supplemental Table 4). This evidence concerns the gene SLC5A2 and hydrops fetalis.