Arsenic modulates Hippo pathway activity by upregulating key proteins like Large Tumor Suppressor Kinase 1/2 (LATS1), Salvador homologue-1 (Sav1) and ste20-like kinase 1/2 (Mst1), which are known to play roles in various cancers, including skin cancer.53, 57. The gene discussed is MST1; the disease is skin cancer.