HLA-E and hemorrhagic fever with renal syndrome: HTNV-derived peptides could be presented by HLA-E on HTNV-infected cells, but they prevent the recognition and interaction between HLA-E and CD94/NKG2A on CD56dimNKG2A+NK cells in the peripheral blood of HFRS patients, thus “abrogating” the inhibitory signal of NKG2A and “relieving” the cytotoxic effects of NK cells against HTNV infection (Fig 14).