The expression of NKG2A on CD56dimCD16+ NK cells showed that both the frequencies and mean fluorescence intensity (MFI) of NKG2A were significantly higher in HFRS patients than in uninfected controls (p<0.05 and p<0.01, respectively); whereas there was no difference in the expression of NKG2C on CD56dimCD16+ NK cells for both frequency and MFI between HFRS patients and uninfected controls (Fig 3C-E). The gene discussed is KLRC2; the disease is hemorrhagic fever with renal syndrome.