Under pathologic conditions, HLA-E could be overexpressed and present pathogen-derived peptides to be recognized by TCR on CD8+ T cells to induce effective CD8+ T cell responses against infection, or interact with CD94/NKG2A on both activated CD8+ T cells and NK cells, producing inhibition to CD8+ T cells and NK cell and contributing to viral immune evasion [15]. This evidence concerns the gene CD8A and infection.