Moreover, we found that the CD56dimNKG2A+NK cells of HFRS patients could produce perforin and express high level of degranulation marker CD107a, while produce similar level of granzyme B compared with uninfected controls in this study, which was in accordance with the previous report that CD56dimNKG2A+CD57-NK cell subset could highly expressed granzyme B in healthy individuals [27]. This evidence concerns the gene PRF1 and hemorrhagic fever with renal syndrome.