The results showed that both the frequency of HLA-DR+CD56dimNKG2A+ NK cells of HFRS patients were significantly higher than that of uninfected controls (p<0.001), as well as Ki-67+CD56dimNKG2A+ NK cells of HFRS patients were also higher than that of uninfected controls (p<0.05) (Fig 11A-D). The gene discussed is MKI67; the disease is hemorrhagic fever with renal syndrome.