Meanwhile, the expression of CD57 on CD56dimCD16+NKG2A+NKG2C- NK cells of HFRS patients were analyzed (Fig 3G), the result of which showed that the frequencies of CD57- NK cells were higher than that of CD57+ NK cells in HFRS patients (p<0.001) (Fig 3H). Here, B3GAT1 is linked to hemorrhagic fever with renal syndrome.