Oxidative stress can serve as either a basis for the initiation of neurodegenerative diseases via the generation of ROS and the release of pro-inflammatory cytokines [46], stimulating an excessive Aβ production or an activator of its progression and increasing the expression of amyloidogenic γ-secretase subunits such as BACE and PSEN [47,48]. The gene discussed is BACE1; the disease is neurodegenerative disease.