Also, according to the transcriptome analysis, NIR light modulated the expression of transcriptional genes that are risk genes for AD [64]: they are GATA2, YY2, RELA, STAT3, JUN, ARNTL, and CREB3L1 in the cortex; and CELF2, GATA2, E2F4, ELK3, CEBPD, and JUND in the hippocampus. The gene discussed is E2F4; the disease is Alzheimer disease.