GCG and Hyperinsulinemia: Although both GLP-1RAs and DPP4is target the incretin pathway, GLP-1RAs demonstrate greater reductions in hemoglobin A1c levels and body weight, improved β-cell and cardiac function, and lower albuminuria.6 These effects may reduce cancer progression by mitigating hyperinsulinemia and inflammation, while also lowering overall mortality through broader health improvements.