A clear repression in hepatic fibrosis was observed in CeO<sub>2</sub>NP-treated groups as demonstrated by significant downregulation in TGF-β1 and p-Smad 2 and 3 proteins and COL1A1, MMP-2, and α-SMA expressions in hepatic tissues. The gene discussed is COL1A1; the disease is Hepatic fibrosis.