KRAS and adenomyosis: This observation suggests two plausible explanations: i) adenomyosis originated from epithelial cells contained in the sampled uterine endometrium, where the KRAS mutation initially occurred, followed by divergent clonal evolution in adenomyosis and uterine endometrium as additional mutations independently accumulated, or ii) adenomyosis did not originate from epithelial cells contained in the sampled uterine endometrium, and the same KRAS mutation independently occurred in both tissues.