Genetic analyses have indicated the involvement of mutations in oncogenes, such as KRAS and PIK3CA, and abnormal gene expression related to excessive estrogen formation and progesterone resistance in adenomyosis (Vannuccini et al. 2017, Inoue et al. 2019, Bulun et al. 2021, Chao et al. 2023). Here, PIK3CA is linked to adenomyosis.