Evidence has been emerging for decades indicating psychedelics,including LSD (lysergic acid), may have beneficial effects for treatmentof depression and trauma, even in extreme cases like posttraumaticstress disorder. For instance, clinicaltrials featuring LSD were reviewed in 2020, and it is widely acceptedthat low doses of LSD and other substances in this class have antidepressanteffects. Further, TrkB and BDNF wereknown to be necessary for psychedelic-induced neuroplasticity, thoughthe mechanism was not established as of 2022. The gene discussed is BDNF; the disease is major depressive disorder.