Meanwhile, STM2457 ameliorated the IMQ‐induced psoriasis‐like phenotype, as evidenced by reduced PASI scores, alleviation of histopathological hallmarks including epidermal hyperplasia, hyperkeratosis, and parakeratosis, as well as downregulated expression of pro‐inflammatory mediators such as Il17a, Il17f, S100a8, and Tnfa (Figure S7, Supporting Information). This evidence concerns the gene S100A8 and Hyperkeratosis.