IL23A and psoriasis: Patients with psoriasis exhibit elevated circulating monocyte levels,[5, 6] predominantly skewed toward the pro‐inflammatory M1 phenotype.[7, 8] Moreover, M1 macrophages and their associated cytokines—including TNFα, IL‐23, and IL‐12—are significantly upregulated in psoriatic lesions, whereas anti‐TNFα therapies have been shown to suppress M1 polarization in affected tissues.[9, 10, 11]