Macrophages are pivotal in the development and persistence of psoriatic lesions by secreting pro‐inflammatory cytokines, including TNFα, IL‐23, and so on.[2, 40] The increased presence of M1 macrophages within psoriatic lesions acts as a major driver of disease progression.[7] Our findings highlight the role of m6A modification in regulating macrophage function in psoriasis, focusing on how m6A modification of SLC15A3 contributes to M1 macrophage polarization, thereby advancing our understanding of immune regulation in psoriasis. This evidence concerns the gene SLC15A3 and psoriasis.