IRAK3 and bacterial infectious disease: While m6A's regulatory impact on macrophage function has been reported, its effects are context‐dependent, varying under different physiological conditions.[12, 13, 14] For example, m6A modification of Socs1 suppresses macrophage inflammation during bacterial infections,[14] whereas m6A modification of Irakm enhances macrophage activation in response to TLR4 ligands.[13] These studies have primarily focused on the TLR4 signaling pathway in macrophages, but the role of m6A in regulating macrophage polarization through TLR7 signaling remains poorly understood.