Beyond impaired wound healing, diabetes is often accompanied by depression and chronic inflammation, which form a depression‐inflammation pathway that further impedes tissue repair.[59, 60] In consideration of this issue, Xie and colleagues proposed a microneedle‐EA integrated system, which promoted the healing of chronic wounds while alleviating depression‐like behaviors in diabetic rats (Figure 3d).[61] Electrical stimulation at acupoint GV14 suppressed systemic inflammation through the vagal‐adrenal axis and elevated serotonin (5‐HT) and FOXP3 levels. This evidence concerns the gene FOXP3 and depressive disorder.