Mutations of PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2), encoding a catalytic subunit of the pyruvate dehydrogenase complex (PDC), have been reported to be associated with male infertility in humans (Yildirim et al., 2018; Kherraf et al., 2022). The gene discussed is PDHA2; the disease is male infertility.