The same trend was present when the frequency of changes in the NOTCH1 gene was compared with that of the CTNNB1 gene—the frequency of changes in the NOTCH1 gene was significantly higher in anaplastic oligodendroglioma (P < 0.05), GBM (P < 0.05), anaplastic astrocytoma (P < 0.05), and diffuse glioma (P < 0.05). The gene discussed is NOTCH1; the disease is glioblastoma.