To examine and interpret data on major genes involved in EMT and associate their changes with low-grade glioma (LGG) and/or high-grade glioma (HGG), data from the cBioPortal—a publicly available database for tumor genomics and transcriptomics, were collected for 13 genes: CDH1, CDH2, CTNNB1, LEF1, NOTCH1, SNAI1, SNAI2, SOX2, TJP1/ZO1, TWIST1, VIM, ZEB1, and ZEB2. The dataset included mutations, copy number alterations, and changes in transcript levels reported for each gene. The gene discussed is ZEB1; the disease is central nervous system cancer.