Furthermore, the frequency of changes in those genes where changes were present was statistically significantly higher in the NOTCH1 gene than in the CDH1 gene in anaplastic oligodendroglioma (Benjamini–Hochberg Adjusted P value, significant using an FDR of 0.05 (P < 0.05), oligodendroglioma (P < 0.05), GBM (P < 0.05), anaplastic astrocytoma (P < 0.05), and diffuse glioma (P < 0.05). This evidence concerns the gene NOTCH1 and anaplastic astrocytoma.