NOTCH1 and central nervous system cancer: Genes in which changes were present in all six pathohistological diagnoses were NOTCH1 and SOX2. Changes of the CDH1 gene were present in 5/6 glioma types, of CTNNB1 and ZEB1 genes in 4/6 pathohistological types, and of CDH2 and TJP1/ZO-1, in 3/6 glioma types.