PROM1 and neuroblastoma: In addition to the role as substrate for cellular migration, the ECM has fundamental roles in modulating cell activities by activating or suppressing specific intracellular signaling pathways.[39] In particular, a previous study indicated that SH‐SY5Y neuroblastoma cells differentiate when grown on LM.[18] However, our SH‐SY5Y cell model of iLIN28B showed elevated levels of the stem‐related CD133 molecular marker, indicating that LIN28B hijacks the pro‐differentiation stimuli provided by LM.