Neuroblastoma is known for its clinical and biological heterogeneity and its possible presentation as a disseminated disease at diagnosis, leading to a poor prognosis.[1] Genomic aberration and overexpression of LIN28B oncogene contributes to this phenotype in a subgroup of HR patients with metastatic disease.[5] The metastatic process is complex and consists of several steps. This evidence concerns the gene LIN28B and metastatic neoplasm.