LIN28B and neoplasm: Our in vivo studies also sustained the role of LIN28B overexpression in the regulation of neuroblastoma metastasis as confirmed in two different zebrafish/neuroblastoma angiogenesis models.[25] The zebrafish model allows the in vivo observation of the multistep metastatic cascade of events, including angiogenesis, tumor‐endothelium cell interaction, and intravasation of cancer cells.[25] In our study, the injection of iLIN28B cells in the zebrafish embryo resulted in a robust angiogenic response, with a rapid recruitment of endogenous blood vessels in close proximity to the tumor mass.