In addition to the role as substrate for cellular migration, the ECM has fundamental roles in modulating cell activities by activating or suppressing specific intracellular signaling pathways.[39] In particular, a previous study indicated that SH‐SY5Y neuroblastoma cells differentiate when grown on LM.[18] However, our SH‐SY5Y cell model of iLIN28B showed elevated levels of the stem‐related CD133 molecular marker, indicating that LIN28B hijacks the pro‐differentiation stimuli provided by LM. Here, LIN28B is linked to neuroblastoma.