INSR and cancer: The dynamics of angiogenic balance in neuroblastoma are intricated and involve the coordinated activity of a spectrum of stimulators and inhibitors.[7] Elevated tumor vascularity is linked to a disseminated disease, MYCN amplification, unfavorable tumor histology, and poor patient outcome.[8] The insulin‐like growth factor 2 (IGF2) and its two receptors, Insulin‐like Growth Factor 1 Receptor (IGF1R) and insulin receptor (IR), have been shown to play a crucial role in promoting angiogenesis and the progression of cancer.[9]