IGF2 and neoplasm: IGFs, particularly IGF1 and IGF2, are critical factors for the proliferation, survival, and differentiation of neural stem cells and glial cells in the nervous system, mostly through the activation of PI3K‐AKT and MAPK signaling pathways.[10] In neuroblastoma, increased IGF2 level has been correlated with poor prognosis and advanced tumor stage.[11] Also, IGF1R signaling has been shown to play an important role in promoting neuroblastoma genesis and in inhibiting apoptosis.