However, considering the different effects on breakfast PPG of lixisenatide as compared with Liraglutide (both given in the morning and associated with BI), with iGlarLixi one should monitor the risk of hypoglycaemia especially in the second half of the morning, whereas with IDegLira the risk might be greater later in the afternoon when insulin resistance is reduced as compared with the morning.74 Here, INS is linked to Hypoglycemia.