Significant differences across AGR quartiles were observed for variables including age, sex, race, education level, marital status, PIR, BMI, smoker status, diabetes mellitus, hypertension, leukocyte, TG, TC, HDL-C, LDL-C, FBG, HbA1c, ALT, albumin, globulin, BUN, eGFR, use of antihypertensive or hypoglycemic agents, CKM stage, all-cause mortality and CVD mortality (all p < 0.05). The gene discussed is GPT; the disease is diabetes mellitus.