Neurodegeneration has been linked to metal ion transport across disease types including Menkes disease which is directly linked to mutations in Atp7a; other neurodegenerative diseases including, Parkinson’s disease, Alzheimer’s disease, frontal temporal dementia and amyotrophic lateral sclerosis (ALS) (Gale and Aizenman, 2024). The gene discussed is ATP7A; the disease is early-onset autosomal dominant Alzheimer disease.