Studies have shown that electroacupuncture stimulation combined with astragaloside IV treatment can effectively alleviate isoproterenol-induced cardiac hypertrophy and myocardial fibrosis in rats, and this regulation is involved in the TGF-β/Smad pathway (Li J. S. et al., 2017). The gene discussed is TGFB1; the disease is Myocardial fibrosis.