TGFB1 and Myocardial fibrosis: Chen G. et al. (2022) showed that calycosin could alleviate myocardial fibrosis and cardiac dysfunction after myocardial infarction in vivo by inhibiting TGF-β/Smad pathway, and inhibit cardiac fibroblasts proliferation and collagen deposition induced by TGF-β1 in vitro.