IFNG and Granuloma: Mechanistically, preclinical models implicate benzodiazepine-induced suppression of IFN-γ-driven autophagy in perivascular macrophages via GABA-A receptor signaling, delaying granuloma resolution—a phenomenon more pronounced in immunocompetent (HIV-negative) individuals (HR = 1.34 versus HIV-positive HR = 0.94).