,25Spp1 expression correlated strongly with Fgf18 expression in multiple murine models of liver fibrosis, including CflarLKO mice with CDE diet-induced fibrosis, hepatocyte-specific Fgf18 transgenic mice, and wild-type mice fed a Western diet and injected with CCl4 (Figures 1D–1F).19 Here, FGF18 is linked to fibrosis.