In this study, we analyzed the polymorphisms in six cell surface TLR genes (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) in striped hamsters, aiming to determine their association with Bartonella infections and ectoparasite parasitism, including fleas and gamasid mites. This evidence concerns the gene TLR5 and bartonellosis.