In the same study, analysis of two independent PC populations—Memorial Sloan Kettering Cancer Center (MSKCC) (n = 130) and The Cancer Genome Atlas (TCGA) Provisional (n = 490)—showed that BChE mRNA levels decreased from WHO Grade Group (WHOGG)-1 to WHOGG-3, but significantly increased in WHOGG-5 tumors. The gene discussed is BCHE; the disease is pachyonychia congenita.