ADCY5 and obesity due to melanocortin 4 receptor deficiency: For instance, on OAR1:188,636,771 was found SNP rs161707914, which was found to be associated with TNB, and close to this SNP is the ADCY5 (adenylate cyclase 5) gene, which encodes an enzyme that catalyzes the conversion of ATP to cAMP, and plays crucial roles in normal biological functions (e.g., lipolysis, gluconeogenesis, and respiration) and pathophysiological states (e.g., diabetes and obesity) (Vatner et al., 2013).