Some genes play important roles in health, such as ADCY5, CACNG6, CACNG7, CACNG8, CTNNA3, ITGAV, LEF1, COX6B2, MYL2, NOS1, PRKAB1, PRKCA, RPS6KA5, and TNNI3, which are components of cardiac pathways, such as hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, adrenergic signaling in cardiomyocytes, and cardiac muscle contraction. The gene discussed is TNNI3; the disease is arrhythmogenic right ventricular cardiomyopathy.