ALB and brain edema: Its inclusion has been shown to reduce extravascular lung water accumulation by decreasing vascular permeability and pulmonary shunt fraction.38, 39 HA in the prime can also mitigate the decline in colloid oncotic pressure during bypass, potentially preventing myocardial, pulmonary, intestinal, and cerebral edema.38, 40 Nevertheless, there is a shortage of extensive randomized controlled trials that directly compare albumin with crystalloid solutions in patients undergoing cardiac surgery.