Emerging evidence indicates that lower serum Klotho levels are associated with increased carotid intima‐media thickness (CIMT) and epicardial fat thickness (EFT), as well as reduced brachial artery flow‐mediated dilation (FMD), suggesting its potential as a predictive biomarker for atherosclerosis development (Keles et al. 2015). This evidence concerns the gene KL and atherosclerosis.