The imbalance between pro‐apoptotic and anti‐apoptotic signaling pathways, along with enhanced survival signaling through nuclear factor‐kappa B (NF‐κB), protein kinase B (AKT), and mitogen‐activated protein kinase (MAPK) pathways, also supported the survival of TRAIL‐resistant renal carcinoma cells (Lemke et al. 2014). This evidence concerns the gene AKT1 and renal carcinoma.