The Mφ-CM contained a number of EMT inducers, including CHI3L1, IL-10, IL-6, IL-8, and TNF-α, which are known to play a role in cancer metastasis, migration, invasion, chemotaxis, and endothelial cell junction retraction [[80], [81], [82], [83], [84]]. Here, CHI3L1 is linked to cancer.