MEbrown was enriched in neuron- and proteostasis-related proteins, including disease-associated proteins such as APOE and VCP (linked to AD and frontotemporal dementia), while MEgreen was enriched in mitochondrial proteins (e.g., NDUFA4, NDUFB11, NDUFS8, and CYC1) involved in the electron transport chain and oxidative phosphorylation (Extended Data Fig. 7e–g and Supplementary Table 8). The gene discussed is CYC1; the disease is frontotemporal dementia.