These findings align with the reduced interferon II (IFNγ) response (Extended Data Fig. 2b) and Stat3 expression in the PS19/P2rx7−/− mousehippocampus (Fig. 4f) and PS19/P2rx7−/− InfM microglia (Fig. 5l), suggesting that P2rx7-mediated IFNγ and STAT3 signaling may be required for microglial conversion to a proinflammatory state in tauopathy and that P2rx7 disruption reduces neuroinflammation. This evidence concerns the gene STAT3 and tauopathy.