We further analyzed ELDR transcripts in a RNA seq dataset5 and two of our in-house glioma stem-like cell (GSC) RNA-seq datasets with strand direction information and found that RNA transcribed from the ELDR locus primarily comes from the plus strand, while the annotated ELDR is transcribed from the negative strand with much less abundance compared to the transcripts originated from the plus strand (Fig. 2a, Extended data, Fig. 2a, b). Here, ELDR is linked to central nervous system cancer.