We found that GSC11 and GBM6 tumor xenografts treated with combined WM-3835 + Erlotinib had significantly lower proliferation indices (by Ki-67 staining) and higher apoptosis levels (by cleaved caspase 3) when compared to WM-3835 or Erlotinib treatment (Fig. 7i, j, Extended data Fig. 7c, d). This evidence concerns the gene CASP3 and neoplasm.