Nevertheless, recent research suggests that plasma extracellular vesicles (EVs) content may serve as potential diagnostic biomarkers.12 Chatterjee et al. demonstrated that EVs in plasma contain quantifiable amounts of TAR DNA-binding protein (TDP-43) and tau isoforms, with distinct patterns observed in diseases like Amyotrophic lateral sclerosis (ALS) and FTD. Here, TARDBP is linked to frontotemporal dementia.