MAPT and Alzheimer disease: The large, well-characterized AD cohort that includes longitudinal data facilitated the identification of potential protein biomarkers predictive of AD-related phenotypes: amyloid-PET (N = 280), tau PET imaging (N = 264), CDR (N = 2,671) and CSF Aβ42/Aβ40 ratio (N = 504, Table 2).