Our analysis also captured AD-associated proteins known to be involved in AD-related pathways, including full-length MAPT, APOE, PSEN1, and BACE, as well as proteins reported to be associated with AD in some large-scale proteomics studies, include NPTXR, ACHE, BDNF, IL7, VEGF-D and VEGF-A37–39. Here, BACE1 is linked to Alzheimer disease.