A recently made available preprint reported that Amplification parameters of the alpha-synuclein seed amplification assay on CSF were distinct between PD data-driven subtypes, suggesting that patients with more aggressive disease (those subtyped as DM) have shorter reaction time, which may reflect higher density of misfolded α-synuclein aggregates in the CSF sample [32]. This evidence concerns the gene SNCA and Parkinson disease.