Although the precise role of these Chlamydia interactome proteins in AD pathology remains unclear, accumulating evidence indicates that these proteins are involved in biological processes relevant to AD, including regulating apoptosis and mitochondrial function (e.g., RTN4, HSPB1, BAG3), modulating inflammatory and synaptic plasticity pathways, endoplasmic reticulum stress (TECR), and clearance of Aβ (LRRFIP1, HSPB1) and tau (BAG3)110,111,159–165. Here, RTN4 is linked to Alzheimer disease.