TLR4 and Alzheimer disease: Additionally, the DNA pathogen sensor and Chlamydia interactor, LRR binding FLII interacting protein 1 (LRRFIP1), which positively regulates TLR4 by competing with FLII actin remodeling protein (FLII) for interaction with MYD88110, was upregulated in both the AD brain and retina (Fig. 2F; Suppl.