CASP1 and Brain atrophy: We found that retinal NLRP3 and Casp1 were very strongly correlated with retinal atrophy, an index of retinal thickness from inner limiting membrane to outer limiting membrane (Fig. 3L; r = 0.82–0.86, p<0.001–0.0001), whereas these markers had moderate correlation with brain atrophy (Fig. 3L; r = 0.41–0.47, p<0.05).