These data suggest that Cp and related NLRP3 inflammasome activation can drive retinal degeneration by promoting apoptotic (CCasp3) and pyroptotic (NGSDMD) cell death pathways (Fig. 3K, L), and eventually lead to retinal atrophy that was parallel to the extent of brain atrophy. The gene discussed is NLRP3; the disease is Retinal atrophy.