To investigate the link between Cp, NLRP3 inflammasome, and neurodegeneration in the AD retina at different disease stages, we applied a quantitative immunohistochemistry analysis on retinal cross-sections from patients with MCI due to AD and AD dementia as compared with matched non-AD individuals with normal cognition (Fig. 3; extended data in Suppl. This evidence concerns the gene NLRP3 and Alzheimer disease.