NFKB1 and peeling skin syndrome: In addition, the abnormal activation of signalling pathways, such as the interferon gamma (IFN-γ) signalling pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling pathway and Toll-like receptor (TLR) signalling pathway, also plays a key role in the pathogenesis of pSS.