With our novel established human 3D in vitro STAT3 psoriasis model, we complement the current selection with an in vitro model that is especially suited for medium throughput screening approaches due to the high reproducibility, that offers a human based alternative to the current STAT3 mouse models and enables further validation of the STAT3 signaling pathway in keratinocytes as drug target. The gene discussed is STAT3; the disease is psoriasis.